Therapeutic Effect of Sepia pharaonis Ink Extract and Ellagic Acid on the Toxicity Induced by Cyclophosphamide in Male Albino Rats

The combination between anticancer drugs and natural products has great attention aiming at exploiting their efficiency reducing systemic toxicity. Subsequently, the current study was constructed to evaluate potential curative role of crude Sepia ink extract (SIE) Ellagic acid (EA) against cyclophosphamide (CP) Male albino rats were divided into five groups (n = 10). All except group I received CP. Group served as a control group, II single dose CP (200 mg/kg, i.p.) III + SIE mg/kg body weight), IV CP+ ‏ EA (60 mg/kg) V weight) mg/kg). Data showed that administration significantly decreased RBCs, WBCs, PLTs count, PCV%, Hb content. Post caused significant elevation in hematological values. Also, treated reduced hepatic renal toxicity induced by treatment, where liver kidney functions (AST, ALT, ALP, creatinine, urea, uric acid) decrease. On other hand, serum albumin T. protein levels increased compared CP-treated groups. results revealed alterations various tissues injury. Natural eliminated